Lupus anticoagulant


المؤلفان Chemist Sherine‏ وSafaa Ali‏ في تحاليل طبية


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Lupus anticoagulantدى بعض معلومات عن تحليل



Lupus anticoagulant (also known as lupus antibody, LA, or lupus inhibitors) is an immunoglobulin[1] that binds to phospholipids and proteins associated with the cell membrane.



Lupus anticoagulant is actually a prothrombotic agent; that is, presence of Lupus anticoagulant antibodies precipitates the formation of thrombi in vivo. Their name derives from their properties in vitro, since in laboratory tests, presence of these antibodies causes an increase in aPTT. It is speculated that the presence of the antibodies interferes with phospholipids utilized to induce in vitro coagulation.




In vivo, it is thought to interact with platelet membrane phospholipids, increasing adhesion and aggregation of platelets; thus its in vivo prothrombotic characteristics.




Lupus anticoagulant testing is used to help determine the cause of an unexplained thrombosis, recurrent miscarriages, or a prolonged PTT test. It is ordered to help determine whether a prolonged PTT is due to a specific inhibitor, such as an antibody against a specific coagulation factor or to a nonspecific inhibitor like the lupus anticoagulant. It may be ordered along with tests for cardiolipin antibody and anti-beta2-glycoprotein I to diagnose antiphospholipid syndrome. If someone has tested positive for the lupus anticoagulant, the series of tests may be done again in several weeks to see if the lupus anticoagulant is transient or persistent.



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